- A Case of Sheehan's Syndrome with Pancytopenia.
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Hyun Suk Lee, Byung Woon Kwon, Jin Hyung Han, Hee Jin Kim
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Endocrinol Metab. 2012;27(1):54-58. Published online March 1, 2012
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DOI: https://doi.org/10.3803/EnM.2012.27.1.54
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 Abstract
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- Sheehan's syndrome is characterized by varying degrees of anterior pituitary dysfunction due to postpartum ischemic necrosis of the pituitary gland after massive bleeding. The spectrum of clinical presentation of Sheehan's syndrome is broad, with changes from nonspecific complaints, such as weakness, fatigue, and anemia, to severe pituitary insufficiency resulting in coma and death. Normochromic anemia is commonly associated with Sheehan's syndrome, but pancytopenia is rarely observed in patients with Sheehan's syndrome. We describe a 57-year-old woman with Sheehan's syndrome who presented with pancytopenia that was treated by hormone replacement with levothyroxine and glucocorticoid.
- Signal Transduction Related Oncogenes in Human Adrenal Cortical Tumor; Gsα Giα, CREB.
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Eun Jig Lee, Kyung Rae Kim, Hyun Chul Lee, Kap Bum Huh, Sung Kil Lim, eun Kyung Jung, Hyung Chun Park, Woo Hee Jung, Dong Whan Shin, Hyun Suk Lee, Yung Dae Yoon
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J Korean Endocr Soc. 1994;9(4):350-357. Published online November 6, 2019
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Abstract
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- Functioning adrenal cortical tumors are originated form a distinct zone(zonna glomerulosa, zonna fasciculata or zonna reticularis) or the transitonal zone of adrenal gland. Each zone of the gland is regulated by their specific hormons or cytokines, and their signal transduction systems are different. The oncogenes of many endocrine tumors were mutated proteins involved in signal transduction, however gip is the only reported oncogene in adrenal cortical tumors. Therefore we decided to reevaluate whether gsp might be detected as an oncogene in several different functioning adrenal tumors, and we also tested whether CREB protein is a tentative oncogene or not. In our study, gsp was not detected in 13 patients, however gip was not also detected unexpectedly. There were no mutations in the phosporylation site of CREB("P" box) in adrenal cushing syndrome. We concluded that gip was not a oncogene detected frequently in adrenal cortical tumor, and CREB protein was not considered as a tentative oncogen, because there might be no amplification of the signals due to its extreme distal component of PKA or PKC system.
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